Electronic Weighing Automatic Data Collection System
The electronic weighing system integrates devices such as electronic scales directly into the network. By simply clicking the output button, the weighing data can be transmitted to the MES (Manufacturing Execution System), displayed on the HMI (Human-Machine Interface) screen, and simultaneously recorded in the original batch production or inspection records. Combined with RFID or BARCODE label technology, this system ensures strict control over material dosage limits. In addition to electronic scales and balances, flowmeters commonly used in liquid pipelines can also enable automatic data collection.
Currently, most companies worldwide, including industry leaders like Pfizer and Merck, use electronic weighing devices that only print a slip via a printer. These slips are then manually affixed to original records, making automatic dosage control unfeasible. In contrast, this technology automatically collects weighing results, integrates them into original batch production or inspection records, and works seamlessly with RFID/BARCODE systems to maintain stringent control over material dosing, enhancing efficiency and reducing human error.
Intelligent step-by-step SOP control system for process specifications
Throughout the production process, SOPs (Standard Operating Procedures) and operational standards are integrated into the MES (Manufacturing Execution System). Through the HMI (Human-Machine Interface) at each workstation and production step, the system enables intelligent control of equipment and personnel. This ensures that all production operations and quality control adhere strictly to SOPs and SMPs (Standard Manufacturing Procedures), fully achieving a parameter-based quality assurance system where “what is produced is qualified.”
Currently, pharmaceutical companies worldwide rely on manual execution of SOPs. This advanced technology revolutionizes process control on intelligent production lines by completely eliminating the root causes of human error. SOP execution no longer depends on employee compliance but is instead enforced through system-driven commands, ensuring precise adherence. As a result, pharmaceuticals are produced to meet quality standards inherently, aligning with QbD (Quality by Design) principles and international advanced quality control levels. This approach guarantees that what is manufactured is both designed and produced to be compliant, significantly enhancing reliability and efficiency in pharmaceutical production.
RFID electronic tag error-free management system
This system leverages tools such as RFID tags, Wireless APs, printers, and wireless/wired card readers, supported by the ERP/MES quality management system, to enable comprehensive RFID-based digital management of material flow throughout the factory. The system covers the entire process, from material procurement and warehousing to material release, workshop receipt, material circulation within workshops, finished product warehousing, distribution, and sales traceability. By minimizing manual handling during material circulation, this technology enhances cost control, batch management, and production efficiency, significantly improving factory production management.
Currently, RFID electronic tags are primarily used in large-scale logistics and warehouse management on a global scale, with limited application in product manufacturing and quality inspection. This technology expands RFID/BARCODE electronic tag and printing applications beyond logistics, integrating them comprehensively into production processes and quality control workflows. This approach not only ensures better traceability and operational efficiency but also elevates quality management standards in manufacturing, offering a seamless and advanced solution for modern industrial needs.
LIMS laboratory information management and production, material management integration system
This technology enables automated inspection requests, automatic data and chart collection from laboratory equipment such as Agilent gas and liquid chromatography workstations, and the automatic generation of inspection records and reports. It streamlines laboratory management through digitalization and integrates barcode technology into laboratory material management, establishing seamless connections with warehouse and production systems.
Currently, LIMS (Laboratory Information Management Systems) worldwide are limited to storing data and charts from testing instruments and manually inputting final batch inspection reports. They lack the capability for intelligent, process-oriented control and automated collection of inspection records and methods. Netorus’s LIMS is the first globally to implement a quality assurance system that automates the collection of inspection records, methods, and reports, significantly advancing the functionality and efficiency of laboratory management.
PAT process analysis technology system
Process Analytical Technology (PAT) serves as an analytical and control system for the production process, ensuring quality control at every stage of manufacturing. This includes inspections to approve raw materials, excipients, and packaging materials before use, process and quality checks at each production step, testing of intermediates, inspections of finished products, and final product review and release. Through these measures, PAT ensures comprehensive quality control throughout the entire production process.
Currently, pharmaceutical companies worldwide only achieve process analysis and parameter release for individual pieces of equipment. PAT, however, enables pharmaceutical enterprises to conduct process analysis of production parameters across the entire production line, providing dynamic, real-time control for releasing quality-standard parameters. This holistic approach enhances quality assurance, operational efficiency, and compliance with regulatory standards, representing a significant advancement in pharmaceutical manufacturing processes.
Parameter release system
Based on the collection of data during the production process and adherence to detailed cGMP/GAMP regulations related to parameter release, this technology establishes a robust product release system to ensure the production of desired outcomes. It enables real-time, online quality management with parameter-based release capabilities, ensuring that all processes meet predefined quality standards.
Currently, pharmaceutical companies worldwide only perform process analysis and parameter release for individual equipment. This technology, however, advances beyond isolated control to achieve comprehensive process analysis and real-time control of production parameters across the entire production line. By dynamically releasing quality standard parameters, it ensures consistent quality, improves operational efficiency, and supports compliance with international quality standards, marking a significant innovation in pharmaceutical manufacturing quality management.
Electronic batch inspection record automatic generation system
Once the initial setup of batch inspection records and reports is completed, the QC team can carry out inspection processes and generate batch inspection reports. These reports are then reviewed by authorized personnel following the predefined approval workflows. The LIMS system progressively enables data collection and upload from laboratory testing equipment while integrating seamlessly with production and warehouse systems, enhancing the efficiency and convenience of LIMS functionality.
Currently, pharmaceutical companies worldwide rely on manual recording of original batch inspection records. Netorus Technology offers a solution to replace manual records with electronic inspection records, eliminating human error and ensuring accuracy and consistency. This innovation supports a fully paperless laboratory environment, improving operational efficiency and aligning with modern quality management standards.
Automatic Generation System of Electronic Batch Production Records
The intelligent step-by-step SOP control system integrates standardized operational procedures into the production process, enabling the automatic generation of original production records. This approach significantly improves the accuracy of production records while preserving traceability of any modifications, enhancing overall production quality control. The FCS (Field Control System) data collection from on-site equipment is a critical prerequisite for the automated generation of batch production records.
Currently, pharmaceutical companies worldwide rely on manually recorded original batch production records, which are prone to human errors and inconsistencies. Netorus Technology’s system provides a solution by replacing manual records with electronic production records, completely eliminating the risk of human error. This transition to digital documentation not only enhances production efficiency but also strengthens compliance with quality standards and regulatory requirements.
Quality Control and Analysis Systems
Raw material and excipient quality control involves supplier evaluation and selection, procurement control, and quality inspection control. Production control includes the regulation of material input and automatic parameter collection during the production process. Product quality control focuses on the quality of intermediates, with procedures in place to initiate OOS (Out of Specification) or OOT (Out of Trend) investigations if intermediate quality does not meet the required standards, followed by appropriate corrective actions. Additionally, product quality tracking ensures automatic sampling of products, with reminders set for pre-defined review dates and automatic prompts for testing.
Currently, pharmaceutical companies worldwide have not fully implemented a comprehensive quality control analysis across the entire process, from raw materials to finished products. This technology, however, enables end-to-end quality control analysis for raw materials, packaging materials, intermediates, and final products throughout the entire pharmaceutical manufacturing process, ensuring consistent product quality and compliance with regulatory standards.
e-Manufacturing/ Virtual manufacturing
In a digital and networked environment, production, operations, and management activities are carried out electronically, including the installation and commissioning of systems such as the NETORUS MES system server, industrial Ethernet, industrial switches, and other related devices, along with the construction of basic infrastructure. This technology is designed to enhance the value of the entire value chain in manufacturing enterprises by connecting production processes with business value, thereby improving market responsiveness and competitive capabilities.
Industrial Ethernet enables companies to implement a cross-regional, cross-border, real-time online management model across their global subsidiaries, facilitating seamless communication and control. This infrastructure supports efficient and synchronized operations, helping enterprises stay competitive in the global market while optimizing management and production processes.
